Comorbidity, multimorbidity and personalized psychosomatic medicine: epigenetics rolling on the horizon.
نویسندگان
چکیده
This review focuses first on conceptual chaos and different connotations in psychosomatic medicine, then on new perspectives on comorbidity and multimorbidity, especially from epigenetics perspective. Comorbidity is one of the greatest research and clinical challenges to contemporary psychiatry and psychosomatic medicine. Recently altered gene expression due to epigenetic regulation has been implicated in the development of multifarious mental disorders and somatic diseases. The potential relevance of epigenetics for better understanding and more successful treatment of comorbidity and multimorbidity is described.
منابع مشابه
Comorbidity and multimorbidity in medicine today: challenges and opportunities for bringing separated branches of medicine closer to each other.
Comorbidity and multimorbidity represent one of the greatest chalenge to academic medicine. Many disorders are often comorbidly expressed in diverse combinations. In clinical practice comorbidity and multimorbidity are underrecognized, underdiagnosed, underestimated and undertreated. So that one can speak about comorbidity and multimorbidity anosognosia. Comorbidities and multimorbidities are i...
متن کاملPsychopharmacotherapy and comorbidity: conceptual and epistemiological issues, dilemmas and controversies.
Comorbidity is one of the greatest research and clinical challenges to contemporary psychiatry. Mental disorders are often comorbidly expressed, both among themselves and with various sorts of somatic diseases and illnesses. Shifting the paradigm from vertical/mono-morbid interventions to comorbidity and multimorbidity approaches enhances effectiveness and efficiency of human resources utilizat...
متن کاملPerson-centered medicine and good clinical practice: disease has to be cured, but the patient has to be healed.
Contemporary medicine has been in the process of a paradigm shift. Instead of relatively broad pathological entities, population-based risk assesments, and non-specific "one-size-fits-all" therapies, a new paradigm of predictive, individualized and personalized care and targeted therapy is rolling on the horizon. Person-centered medicine is a term with different meanings which competes in some ...
متن کاملMulti-period and multi-resource operating room scheduling and rescheduling using a rolling horizon approach: a case study
In this paper, a multi-period and multi-resource operating room (OR) scheduling and rescheduling problem with elective and semi-elective (semi-urgent) patients is addressed. A scheduling-rescheduling framework based on the so-called rolling horizon approach is proposed to solve the problem. The core of the proposed framework is a novel proposed mixed-integer linear programming (MILP) model with...
متن کاملComorbidity as an epistemological challenge to modern psychiatry
In spite of a considerable progress in comorbidity research and huge literature on it, this phenomenon is one of the greatest epistemological, research and clinical challenges to contemporary psychiatry and medicine. Mental disorders are very often comorbidly expressed, both among themselves and with various sorts of somatic diseases and illnesses. Therefore, comorbidity studies have been expec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Psychiatria Danubina
دوره 22 2 شماره
صفحات -
تاریخ انتشار 2010